EFFECT OF A PREPREGNANCY PERTUSSIS BOOSTER DOSE ON MATERNAL ANTIBODY TITERS IN YOUNG INFANTS

被引:76
|
作者
Leuridan, Elke [1 ]
Hens, Niel [2 ,3 ]
Peeters, Natasja [1 ]
de Witte, Liene [1 ]
Van der Meeren, Olivier [4 ]
Van Damme, Pierre [1 ]
机构
[1] Univ Antwerp, Ctr Evaluat Vaccinat, Vaccine & Infect Dis Inst, WHO Collaborating Ctr Control & Prevent Infect Di, B-2020 Antwerp, Belgium
[2] Univ Antwerp, Vaccine & Infect Dis Inst, CHERMID, Fac Med, B-2020 Antwerp, Belgium
[3] Univ Hasselt, Hasselt, Belgium
[4] GlaxoSmithKline Biol, Rixensart, Belgium
关键词
neonatal pertussis; maternal antibodies; booster vaccination; ACELLULAR PERTUSSIS; DIPHTHERIA; TETANUS; VACCINES; IMMUNIZATION; PROTECTION;
D O I
10.1097/INF.0b013e3182093814
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To examine the influence of a pertussis booster vaccination on the transfer of maternal antibodies, 24 nonpregnant women received a tetanus, diphtheria, acellular pertussis booster vaccine between 2 consecutive pregnancies. Blood was drawn from mothers and off-spring. Efficient transplacental antibody transfer and significantly higher antibody titers against 3 pertussis antigens were observed in cord blood and in blood of 1-month-old infants born after a maternal booster vaccination compared with results in their siblings born before the booster administration.
引用
收藏
页码:608 / 610
页数:3
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