Use of posaconazole delayed-release tablets for treatment of invasive aspergillosis

被引：5
|
作者：
Conant, Marjorie M. [1 ]
Sha, Beverly E. [1 ]
Proia, Laurie A. [1 ]
机构：
[1] Rush Univ, Div Infect Dis, Med Ctr, Chicago, IL 60612 USA
来源：
MYCOSES | 2015年 / 58卷 / 05期
关键词：
Posaconazole; antifungal therapy; aspergillus; invasive mould infection; PHARMACOKINETICS; SAFETY; TRIAL;
D O I：
10.1111/myc.12309
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
A 65-year-old man developed Aspergillus brain abscesses following surgical resection of a sinus aspergilloma. He was treated with voriconazole for 1year but infection recurred. We elected to treat with posaconazole delayed-release tablets, currently only indicated as antifungal prophylaxis in high-risk patients. A maintenance dose of 300mg Q24h resulted in a therapeutic serum concentration and appears safe and clinically effective thus far. This is the first report of successful use of posaconazole tablets for treatment of invasive aspergillosis.
引用
收藏
页码：313 / 314
页数：2
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