Central and renal hemodynamics in hypertensive men and women aged 40-60 years

Aim. To investigate renal hemodynamics features and their interactions with cardiovascular system structure and function in patients with essential arterial hypertension (EAH), aged 40-60 years. Material and methods. In total, 102 EAH patients (35 men, 67 women) aged 40-60 years were examined. Myocardial morphology and function was assessed by echocardiography. Renal hemodynamics and total glomerular filtration rate (TGFR) was assessed by dynamic angionephroscintigraphy. Results. In women, renal blood flow and TGFR were significantly lower than in men. Gender difference was observed for left ventricular myocardial mass (LVMM) index and total peripheral vascular resistance (TPVR): 141,3 g/cm2 vs 111,2 g/cm2 (p=0,000), and 1109 +/- 321 dyn/s/cm5 vs 1343 +/- 507 dyn/s/cm5 (p=0,012) in men and women, respectively. In men, moderate positive correlation was registered between TGFR and TPVR (r=0,54; p<0,05); in women - moderate negative correlation between TGFR and LVMM index (r=-0,335; p<0,05), TGFR and body mass index, BMI (r=-0,414; p<0,05). Conclusion. In EAH women aged 40-60 years, renal hemodynamics and TGFR parameters were significantly lower than in men. Men demonstrated moderate positive correlation between TGFR and TPVR, women - moderate negative correlation between TGFR and LVMM index, TGFR and BMI.