MiR-101-3p Suppresses Progression of Cervical Squamous Cell Carcinoma by Targeting and Down-Regulating KPNA2

被引：8
|
作者：
Wang, Hong [1 ]
Xiao, Rongxin [1 ]
Yang, Biao [1 ]
机构：
[1] Funing Peoples Hosp, Funing, Jiangsu, Peoples R China
来源：
TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2021年 / 20卷
关键词：
microRNA-101-3p; KPNA2; cervical squamous cell carcinoma; proliferation; migration; invasion; CANCER; PROLIFERATION; ALPHA-2;
D O I：
10.1177/15330338211055948
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective We explored mechanism of microRNA-101-3p/Karyopherin alpha 2 (KPNA2) axis in cervical squamous cell carcinoma. Methods: Bioinformatics methods were applied to identify genes for the study. Cell functional assays were implemented to examine the role of the genes in malignant progression of cervical squamous cell carcinoma. Targeting relationship between genes was verified by dual-luciferase assay. Results: MicroRNA-101-3p was lowly expressed in cervical squamous cell carcinoma, while KPNA2 was highly expressed. Dual-luciferase assay identified direct targeting relationship between microRNA-101-3p and KPNA2. Functional assays manifested that highly expressed microRNA-101-3p suppressed cervical squamous cell carcinoma cell growth by targeting KPNA2. Conclusion: Overall, microRNA-101-3p/KPNA2 axis can play an important part in progression of cervical squamous cell carcinoma.
引用
收藏
页数：7
相关论文
共 50 条
  • [21] MiR-34a-5p suppresses cutaneous squamous cell carcinoma progression by targeting SIRT6
    Chen, Sai
    Yuan, Muxing
    Chen, Hongxia
    Wu, Tong
    Wu, Tianqi
    Zhang, Dongmei
    Miao, Xu
    Shi, Jian
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 2024, 316 (06)
  • [22] CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progressionThe role of the CREB1/miR-495-3p/KPNA2 axis in melanoma progression
    Xuerui Geng
    Xiujuan Qiu
    Jun Gao
    Zhifan Gong
    Xiaogang Zhou
    Chunlei Liu
    Haichao Luo
    BMC Molecular and Cell Biology, 23
  • [23] miR-26 suppresses renal cell cancer via down-regulating coronin-3
    Xin Jun Wang
    Zhi Jian Yan
    Guang Cheng Luo
    Yi Yan Chen
    Pei Ming Bai
    Molecular and Cellular Biochemistry, 2020, 463 : 137 - 146
  • [24] miR-532-3p inhibits the progression of tongue squamous cell carcinoma by targeting podoplanin
    Zhi-Yun Liu
    Chun-Guang Zhao
    中华医学杂志英文版, 2021, 134 (24) : 2999 - 3008
  • [25] miR-532-3p inhibits the progression of tongue squamous cell carcinoma by targeting podoplanin
    Liu, Zhi-Yun
    Zhao, Chun-Guang
    CHINESE MEDICAL JOURNAL, 2021, 134 (24) : 2999 - 3008
  • [26] miR-26 suppresses renal cell cancer via down-regulating coronin-3
    Wang, Xin Jun
    Yan, Zhi Jian
    Luo, Guang Cheng
    Chen, Yi Yan
    Bai, Pei Ming
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2020, 463 (1-2) : 137 - 146
  • [27] LncRNA SNHG22 promotes gastric cancer progression by regulating the miR-101-3p/e2f2 axis
    Li, Zhen
    Lang, Zhiqiang
    Wang, Ting
    Qu, Guimei
    Sui, Wu
    Liu, Jing
    CELL CYCLE, 2023, 22 (03) : 347 - 360
  • [28] LINC00052/miR-101-3p axis inhibits cell proliferation and metastasis by targeting SOX9 in hepatocellular carcinoma
    Yan, Shaoying
    Shan, Xuefeng
    Chen, Ke
    Liu, Yuyang
    Yu, Gangfeng
    Chen, Qiuxu
    Zeng, Tao
    Zhu, Liying
    Dang, Hao
    Chen, Fengjiao
    Lin, Jiaji
    Huang, Ailong
    Tang, Hua
    GENE, 2018, 679 : 138 - 149
  • [29] LncRNA MCM3AP-AS1 inhibits cell proliferation in cervical squamous cell carcinoma by down-regulating miRNA-93
    Lan, Liu
    Liang, Zhishan
    Zhao, Yingxi
    Mo, Yuzhen
    BIOSCIENCE REPORTS, 2020, 40
  • [30] CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression The role of the CREB1/miR-495-3p/KPNA2axis in melanoma progression
    Geng, Xuerui
    Qiu, Xiujuan
    Gao, Jun
    Gong, Zhifan
    Zhou, Xiaogang
    Liu, Chunlei
    Luo, Haichao
    BMC MOLECULAR AND CELL BIOLOGY, 2022, 23 (01)
12345