Classification of Hub Protein and Analysis of Hot Regions in Protein-Protein Interactions

Proteins are fundamental to most biological processes, which accomplish a vast amount of functions by interacting with other proteins. The research of PPI (protein-protein interaction) and its network has developed into a great importance part in bioinformatics. In the protein-protein interaction networks, most proteins interact with only a few partners, and small number of proteins interact with many partners, these proteins are called hub proteins. The hub proteins can be divided into party hub and date hub. Therefore, in this paper, we do some works about hub proteins. In addition, this paper uses the connectivity and betweenness to classify the hub protein in protein-protein interaction network. On the other hand, the paper studies hub proteins from another perspective (interfaces conformation), which reflects the organization of hot spot residues in hub protein interface.