Testing whether hot regions in protein-protein interactions are conserved in different species

被引：0
|
作者：
Hu, Jing [1 ,2 ]
Zhang, Xiaolong [1 ,2 ]
机构：
[1] Wuhan Univ Sci & Technol, Sch Comp Sci & Technol, Wuhan, Peoples R China
[2] Hubei Prov Key Lab Intelligent Informat Proc & Re, Wuhan, Peoples R China
来源：
PROCEEDINGS 2015 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE | 2015年
关键词：
hot region; protein-protein interaction; conservation; different species; BLOSUM; DATABASE; ORGANIZATION; INTERFACES; RESIDUES; BINDING; SITES;
D O I：
暂无
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
We examined the conservation of hot regions in protein-protein interaction in evolution for the first time. We studied sequence conservation of hot regions in different species annotated in the database ASEdb, applying the BLOSUM matrix to construct conservation scoring function of hot regions. The experimental results showed that there is high correlation of conservation between hot regions in different species. We further tested the conservation of hot regions in different species annotated in the latest SKEMPI database using the same method. Our experimental results suggest that there is obvious conservation in hot regions.
引用
收藏
页码：1624 / 1629
页数：6
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