A comprehensive evaluation for polymorphisms in let-7 family in cancer risk and prognosis: a system review and meta-analysis

被引:17
|
作者
Wang, Ben-Gang [1 ,2 ]
Jiang, Li-Yue [3 ]
Xu, Qian [2 ]
机构
[1] China Med Univ, Hosp 1, Dept Gen Surg 1, Shenyang 110001, Liaoning, Peoples R China
[2] China Med Univ, Hosp 1, Inst Gen Surg, Shenyang 110001, Liaoning, Peoples R China
[3] Fourth Mil Med Univ, Clin Med, Xian 710000, Shanxi, Peoples R China
关键词
SINGLE NUCLEOTIDE POLYMORPHISM; TRIAL SEQUENTIAL-ANALYSIS; CELL-DIFFERENTIATION; PROMOTER REGION; LUNG-CANCER; MICRORNA; BIOGENESIS; CARCINOMA; CHINESE; BIAS;
D O I
10.1042/BSR20180273
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
miRNA polymorphisms had potential to be biomarkers for cancer susceptibility and prognosis. The mature miRNA-let-7 family was considered as the most important miRNA for the cancer incidence and progression. Recently, the promising let-7 miRNAs were reported to be associated with various cancers, but the results were inconsistent. We performed a first-reported systematic review with a meta-analysis for the association of let-7 family single nucleotide polymorphisms (SNPs) with cancer risk/prognosis. Ten studies were included with a total of 3878 cancer cases and 4725 controls for the risk study and 1665 cancer patients for the prognosis study in this meta-analysis. In the risk study, the let-7i rs10877887 and let-7a-1/let-7f-1/let-7d rs13293512 were shown no significant association for the overall cancer risk. In the stratified analysis, the rs10877887 variant genotype was significantly associated with a decreased cancer risk in head and neck cancer (TC compared with TT: P=0.017; odds ratio (OR) = 0.81; TC + CC compared with TT: P=0.020; OR = 0.82). In the prognosis study, the let-7i rs10877887 SNP was shown to be associated with a higher risk for cancer prognosis in the dominate model (P=0.004; hazard ratio (HR) = 1.32). The other two SNPs (let-7a-1 rs10739971 and let-7a-2 rs629367) were not found to be associated with cancer survival. None of the let-7 family polymorphisms had potential to be biomarkers for cancer susceptibility but let-7i rs10877887 SNP had potential to be predicting markers for cancer prognosis. In the future, large-sample studies are still needed to verify our findings.
引用
收藏
页数:11
相关论文
共 50 条
  • [21] A comprehensive evaluation of single nucleotide polymorphisms associated with atrophic gastritis risk A protocol for systematic review and network meta-analysis
    Tang, Zhen-Yu
    Ye, Zhuo-Miao
    Zheng, Jing-Hui
    Jiang, Feng
    Tang, You-Ming
    MEDICINE, 2020, 99 (29) : E20677
  • [22] Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk
    Xu, Yeqiong
    He, Bangshun
    Pan, Yuqin
    Deng, Qiwen
    Sun, Huiling
    Li, Rui
    Gao, Tianyi
    Song, Guoqi
    Wang, Shukui
    TUMOR BIOLOGY, 2014, 35 (05) : 4153 - 4169
  • [23] Polymorphisms of progesterone receptor and ovarian cancer risk: A systemic review and meta-analysis
    Liao, Jing
    Ding, Dong
    Sun, Chaoyang
    Weng, Danhui
    Meng, Li
    Chen, Gang
    Ma, Ding
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2015, 41 (02) : 178 - 187
  • [24] A Systematic Review and Meta-Analysis for the Association of Gene Polymorphisms in RAN with Cancer Risk
    Li, Yanke
    Zhang, Fuqiang
    Xing, Chengzhong
    DISEASE MARKERS, 2020, 2020
  • [25] Association between PXR polymorphisms and cancer risk: a systematic review and meta-analysis
    Wen, Jing
    Lv, Zhi
    Ding, Hanxi
    Fang, Xinxin
    Sun, Mingjun
    BIOSCIENCE REPORTS, 2018, 38
  • [26] Family history and the risk of breast cancer: A systematic review and meta-analysis
    Pharoah, PDP
    Day, NE
    Duffy, S
    Easton, DF
    Ponder, BAJ
    INTERNATIONAL JOURNAL OF CANCER, 1997, 71 (05) : 800 - 809
  • [27] Family History and Risk of Endometrial Cancer A Systematic Review and Meta-analysis
    Win, Aung Ko
    Reece, Jeanette C.
    Ryan, Shae
    OBSTETRICS AND GYNECOLOGY, 2015, 125 (01): : 89 - 98
  • [28] NAT1 polymorphisms and cancer risk: a systematic review and meta-analysis
    Zhang, Kunyi
    Gao, Lijuan
    Wu, Yuqi
    Chen, Jianyi
    Lin, Chengguang
    Liang, Shaohua
    Su, Jianxin
    Ye, Jinming
    He, Xuyu
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (06): : 9177 - 9191
  • [29] Genetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysis
    Jin Zining
    Xu Lu
    He Caiyun
    Yuan Yuan
    ONCOTARGET, 2016, 7 (35) : 57464 - 57480
  • [30] A systematic review and meta-analysis of family history and risk of ovarian cancer
    Stratton, JF
    Pharoah, P
    Smith, SK
    Easton, D
    Ponder, BAJ
    BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1998, 105 (05): : 493 - 499