A comprehensive evaluation for polymorphisms in let-7 family in cancer risk and prognosis: a system review and meta-analysis

被引:17
|
作者
Wang, Ben-Gang [1 ,2 ]
Jiang, Li-Yue [3 ]
Xu, Qian [2 ]
机构
[1] China Med Univ, Hosp 1, Dept Gen Surg 1, Shenyang 110001, Liaoning, Peoples R China
[2] China Med Univ, Hosp 1, Inst Gen Surg, Shenyang 110001, Liaoning, Peoples R China
[3] Fourth Mil Med Univ, Clin Med, Xian 710000, Shanxi, Peoples R China
关键词
SINGLE NUCLEOTIDE POLYMORPHISM; TRIAL SEQUENTIAL-ANALYSIS; CELL-DIFFERENTIATION; PROMOTER REGION; LUNG-CANCER; MICRORNA; BIOGENESIS; CARCINOMA; CHINESE; BIAS;
D O I
10.1042/BSR20180273
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
miRNA polymorphisms had potential to be biomarkers for cancer susceptibility and prognosis. The mature miRNA-let-7 family was considered as the most important miRNA for the cancer incidence and progression. Recently, the promising let-7 miRNAs were reported to be associated with various cancers, but the results were inconsistent. We performed a first-reported systematic review with a meta-analysis for the association of let-7 family single nucleotide polymorphisms (SNPs) with cancer risk/prognosis. Ten studies were included with a total of 3878 cancer cases and 4725 controls for the risk study and 1665 cancer patients for the prognosis study in this meta-analysis. In the risk study, the let-7i rs10877887 and let-7a-1/let-7f-1/let-7d rs13293512 were shown no significant association for the overall cancer risk. In the stratified analysis, the rs10877887 variant genotype was significantly associated with a decreased cancer risk in head and neck cancer (TC compared with TT: P=0.017; odds ratio (OR) = 0.81; TC + CC compared with TT: P=0.020; OR = 0.82). In the prognosis study, the let-7i rs10877887 SNP was shown to be associated with a higher risk for cancer prognosis in the dominate model (P=0.004; hazard ratio (HR) = 1.32). The other two SNPs (let-7a-1 rs10739971 and let-7a-2 rs629367) were not found to be associated with cancer survival. None of the let-7 family polymorphisms had potential to be biomarkers for cancer susceptibility but let-7i rs10877887 SNP had potential to be predicting markers for cancer prognosis. In the future, large-sample studies are still needed to verify our findings.
引用
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页数:11
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