Antimalarial activity of 2,4,6-trisubstituted pyrimidines

被引：36
|
作者：
Agarwal, A
Srivastava, K
Puri, SK
Chauhan, PMS [1 ]
机构：
[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 07期
关键词：
dihydrofolate reductase; antimalarial; pyrimidine;
D O I：
10.1016/j.bmcl.2005.02.015
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 2,4,6-trisubstituted pyrimidines (3a-o) was synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 15 compounds synthesized 11 compounds showed MIC in the range of 0.5-2 mu g/mL. These compounds are in vitro several folds more active than pyrimethamine. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1881 / 1883
页数：3
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