Non-invasive prenatal diagnosis and determination of fetal Rh status

被引：60

作者：

van der Schoot, C. Ellen ^{[1
,2
]}

Hahn, Sinuhe ^{[3
]}

Chitty, Lyn S. ^{[4
,5
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Landsteiner Lab, NL-1066 CX Amsterdam, Netherlands

[2] Sanquin Res, Amsterdam, Netherlands

[3] Univ Basel Hosp, Univ Womens Hosp, Dept Res, Basel, Switzerland

[4] UCL Hosp, NHS Fdn Trust, Fetal Med Unit, London, England

[5] UCL Hosp, NHS Fdn Trust, Clin & Mol Genet Unit, Inst Child Hlth, London, England

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2008年 / 13卷 / 02期

关键词：

fetal RHD status; non-invasive prenatal; diagnosis; cell-free fetal DNA;

D O I：

10.1016/j.siny.2007.12.012

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

RhD blood group incompatibility between a pregnant woman and her fetus can result in maternal alloimmunization and consequent haemolytic disease of the newborn (HDN) in subsequent pregnancies. The D-negative blood group is found in 15% of whites, 3-5% of black Africans, and is rare in Asians. Recent technological advances in non-invasive prenatal determination of the fetal RHD status using cell-free fetal DNA (cffDNA) have opened new avenues for the management of D-negative pregnant women. In this review applications for the high risk women, as well as potential for routine screening wilt be discussed. The use of non-invasive prenatal diagnosis and the management of other blood incompatibilities wilt also be discussed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：63 / 68

页数：6

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