Drug discovery for neglected tropical diseases at the Sandler Center

被引：1

作者：

Robertson, Stephanie A. ^{[1
]}

Renslo, Adam R. ^{[2
]}

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Chem, Sandler Ctr Drug Discovery, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, Small Mol Discovery Ctr, San Francisco, CA 94158 USA

来源：

FUTURE MEDICINAL CHEMISTRY | 2011年 / 3卷 / 10期

基金：

美国国家卫生研究院;

关键词：

TRYPANOSOMA-CRUZI; CHAGAS-DISEASE; CATHEPSIN-K; UP-REGULATION; INHIBITORS; BIOSYNTHESIS; TIPIFARNIB; RESISTANCE; DESIGN; BRUCEI;

D O I：

10.4155/FMC.11.85

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Sandler Center's approach to target-based drug discovery for neglected tropical diseases is to focus on parasite targets that are homologous to human targets being actively investigated in the pharmaceutical industry. In this way we attempt to use both the know-how and actual chemical matter from other drug-development efforts to jump start the discovery process for neglected tropical diseases. Our approach is akin to drug repurposing, except that we seek to repurpose leads rather than drugs. Medicinal chemistry can then be applied to optimize the leads specifically for the desired antiparasitic indication.

引用

页码：1279 / 1288

页数：10

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