Effect of dopamine content in rat brain striatum on anesthetic requirement: an in vivo microdialysis study

被引：5
|
作者：
Onozawa, H [1 ]
Miyano, K [1 ]
Tanifuji, Y [1 ]
机构：
[1] Jikei Univ, Sch Med, Dept Anesthesiol, Minato Ku, Tokyo, Japan
来源：
BRAIN RESEARCH | 1999年 / 817卷 / 1-2期
关键词：
anesthetic requirement; MAC; striatum; dopamine content; in vivo microdialysis;
D O I：
10.1016/S0006-8993(98)01110-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study investigated the changes in anesthetic requirement caused by administration of two different concentrations (0.1 mu M and 1.0 mu M/h) of dopamine into the rat striatum. During the measurement of minimum alveolar concentration (MAC), each dopamine solution was continuously injected directly into rat striatum by microdialysis technique. During perfusion of the lower dose, MAC did not change. During the higher dose of dopamine, MAC decreased by approximately 30%. (C) 1999 EIsevier Science B.V.
引用
收藏
页码：192 / 195
页数：4
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