Development of a New Family of Chiral Auxiliaries

被引：7

作者：

Gelat, Fabien ^{[1
]}

Richard, Vincent ^{[1
]}

Berger, Olivier ^{[1
]}

Montchamp, Jean-Luc ^{[1
]}

机构：

[1] Texas Christian Univ, Dept Chem, Ft Worth, TX 76129 USA

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 08期

基金：

美国国家科学基金会;

关键词：

CONVENIENT SYNTHESIS; NUCLEOPHILIC-ADDITION; ASYMMETRIC INDUCTION;

D O I：

10.1021/acs.orglett.5b00278

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new family of chiral auxiliaries designed on a conformationally restricted version of (-)-8-phenylmenthol has been developed. Both enantiomers are available from an inexpensive synthesis conducted on multigram scale. A first application has showed comparable diastereoselectivity between the novel auxiliary and (-)-8-phenylmenthol.

引用

页码：1819 / 1821

页数：3

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