Development of a New Family of Chiral Auxiliaries

被引：7
|
作者：
Gelat, Fabien [1 ]
Richard, Vincent [1 ]
Berger, Olivier [1 ]
Montchamp, Jean-Luc [1 ]
机构：
[1] Texas Christian Univ, Dept Chem, Ft Worth, TX 76129 USA
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 08期
基金：
美国国家科学基金会;
关键词：
CONVENIENT SYNTHESIS; NUCLEOPHILIC-ADDITION; ASYMMETRIC INDUCTION;
D O I：
10.1021/acs.orglett.5b00278
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new family of chiral auxiliaries designed on a conformationally restricted version of (-)-8-phenylmenthol has been developed. Both enantiomers are available from an inexpensive synthesis conducted on multigram scale. A first application has showed comparable diastereoselectivity between the novel auxiliary and (-)-8-phenylmenthol.
引用
收藏
页码：1819 / 1821
页数：3
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