Reliance on vascular responses for the maintenance of blood pressure in healthy older adults-Insights from the Valsalva maneuver

被引：1
|
作者：
Hockin, Brooke C. D. [1 ]
Taha, Omnia M. [1 ]
Claydon, Victoria E. [1 ]
机构：
[1] Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC V5A 156, Canada
来源：
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2021年 / 236卷
关键词：
Valsalva maneuver; Age; Sex; Orthostatic tolerance; SYMPATHETIC NEURAL RESPONSES; ARTERIAL-PRESSURE; CARDIAC-OUTPUT; VOLUME; SYNCOPE; FLOW; POPULATION; HUMANS; GENDER; HEART;
D O I：
10.1016/j.autneu.2021.102898
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Effective baroreflex-mediated cardiac and vascular resistance responses are crucial for homeostatic blood pressure control. We investigated the impacts of age and sex on arterial blood pressure regulation during a standard supine Valsalva maneuver (40 mmHg, 20s) in 46 healthy young and 25 healthy older adults. Noninvasive, continuous cardiovascular parameters were recorded. In older adults, cardiac output (older: -58.4 +/- 2.4%; young: -40.8 +/- 1.4%; p < 0.001) and stroke volume (older: -63.6 +/- 2.6%; young: -48.7 +/- 1.9%; p < 0.001) fell more than in young adults and was compensated by augmented vascular resistance responses (older: +189.8 +/- 17.6%; young: +105.8 +/- 6.7; p < 0.001); heart rate responses were attenuated in older adults. Male and female responses were comparable in their respective age groups.
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页数：5
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