Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in Sao Paulo, Brazil

被引：5
|
作者：
Mantovani, N. P. [1 ]
Azevedo, R. G. [1 ]
Rabelato, J. T. [2 ]
Sanabani, S. [3 ]
Diaz, R. S. [1 ]
Komninakis, S. V. [1 ]
机构：
[1] Fed Univ Sao Paulo UNIFESP, Div Infect Dis, Retrovirol Lab, Sao Paulo, Brazil
[2] Lusiada Fdn Santos, Mol Biol Lab, Dept Med, Santos, Brazil
[3] Univ Sao Paulo, Div Clin Immunol & Allergy, Sao Paulo, Brazil
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
INTEGRASE INHIBITORS; GENETIC DIVERSITY; DRUG-RESISTANCE; NAIVE; SUBTYPES;
D O I：
10.1128/JCM.00539-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.
引用
收藏
页码：2122 / 2125
页数：4
相关论文
共 50 条
  • [11] Prevalence of HIV-1 transmitted drug resistance and viral suppression among recently diagnosed adults in SAo Paulo, Brazil
    Ozorio Coelho, Luana Portes
    Matsuda, Elaine Monteiro
    Nogueira, Roberta Schiavon
    de Moraes, Monica Jacques
    Jamal, Leda Fatima
    Ramalho Madruga, Jose Valdez
    Tancredi, Mariza Vono
    Queiroz de Leao, Aline Carralas
    Romero Soldi, Giselle de Faria
    de Macedo Brigido, Luis Fernando
    Colpas, Daniela Rodrigues
    Cabral, Gabriela Bastos
    Lopes, Giselle Ibete Silva Lopez
    Campos, Norberto Camilo
    Ribeiro, Isadora Coutinho
    Ahagon, Cintia Mayumi
    Teixeira, Guilherme Penteado
    Ferreira, Joao Leandro de Paula
    de Campos, Ivana Barros
    Carvalho, Mariana
    Gomes, Rafaella
    Pinheiro, Flavia Gennari
    Pereira, Luiz Carlos, Jr.
    Morejon, Karen
    da Costa, Alvaro Furtado
    Kalmar, Erika Maria do Nascimento
    Nogui, Fabio Luis Nascimento
    Nogui, Fabio Luis Nascimento
    Mueller, Patricia Rady
    Goulart, Silvia Pereira
    Leme, Suzana Toledo da Silva
    [J]. ARCHIVES OF VIROLOGY, 2019, 164 (03) : 699 - 706
  • [12] Prevalence of Transmitted HIV-1 Drug Resistance Mutations in Children and Adolescents in Sao Paulo, Brazil
    Almeida, Flavia Jacqueline
    Rodrigues, Rosangela
    Zaparoli, Mayra Simioni
    Berezin, Eitan Naaman
    Palazzi Safadi, Marco Aurelio
    de Paula Ferreira, Joao Leandro
    Lanca, Andre Minhoto
    de Macedo Brigido, Luis Fernando
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2012, 31 (12) : E255 - E257
  • [13] Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil
    Paula Ferreira, Joao Leandro
    Rodrigues, Rosangela
    Lanca, Andre Minhoto
    de Almeida, Valeria Correia
    Rocha, Simone Queiroz
    Ragazzo, Taisa Grotta
    Estevam, Denise Lotufo
    de Macedo Brigido, Luis Fernando
    [J]. ADVANCES IN VIROLOGY, 2013, 2013
  • [14] Seroprevalence of human herpesvirus 8 infection in children born to HIV-1-infected women in Sao Paulo, Brazil
    Machado, DM
    Sumita, LM
    Pannuti, CS
    Succi, RCM
    Moraes-Pinto, MI
    Souza, VAUF
    [J]. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2005, 38 (02) : 237 - 240
  • [15] Sexually transmitted diseases in HIV-1-infected patients
    Medland, N
    [J]. LANCET, 2001, 357 (9267): : 1533 - 1534
  • [16] Transmitted Drug Resistance Among Recently Diagnosed Adults and Children in Sao Paulo, Brazil
    de Souza Guimaraes, Paula Morena
    de Paula Ferreira, Joao Leandro
    Ozorio Coelho, Luana Portes
    Cavalcanti, Jaqueline de Souza
    Silva Lopez Lopes, Giselle Ibette
    Matsuda, Elaine Monteiro
    Almeida, Flavia Jacqueline
    Almeida, Valeria Correia
    Campeas, Alexandre Ely
    Pereira Junior, Luiz Carlos
    de Macedo Brigido, Luis Fernando
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2015, 31 (12) : 1219 - 1224
  • [17] YELLOW FEVER PREVENTION STRATEGIES AWARENESS AMONG HIV-INFECTED PATIENTS IN SAO PAULO, BRAZIL
    Avelino-Silva, Vivian Iida
    Francelino, Hilario Sousa
    Kallas, Esper Georges
    [J]. REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, 2014, 56 (05): : 417 - 420
  • [18] Transmitted HIV Resistance Among Pregnant Young Women Infected with HIV-1 in Brazil
    da Costa, Zelma Bernades
    Ramos de Lima, Yanna Andressa
    Turchi Martelli, Celina Maria
    de Araujo Stefani, Mariane Martins
    [J]. AIDS PATIENT CARE AND STDS, 2013, 27 (08) : 439 - 441
  • [19] Diabetes, insulin resistance, and dementia among HIV-1-infected patients
    Valcour, VG
    Shikuma, CM
    Shiramizu, BT
    Williams, AE
    Watters, MR
    Poff, PW
    Grove, JS
    Selnes, OA
    Sacktor, NC
    [J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2005, 38 (01) : 31 - 36
  • [20] Evaluation of IgG, IgM, and IgA antibodies to Mycoplasma penetrans detected by ELISA and immunoblot in HIV-1-infected and STD patients, in Sao Paulo, Brazil
    de Cordova, CMM
    Takei, K
    Rosenthal, C
    Miranda, MARB
    Vaz, AJ
    da Cunha, RAF
    [J]. MICROBES AND INFECTION, 1999, 1 (13) : 1095 - 1101
12345