Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in Sao Paulo, Brazil

被引：5
|
作者：
Mantovani, N. P. [1 ]
Azevedo, R. G. [1 ]
Rabelato, J. T. [2 ]
Sanabani, S. [3 ]
Diaz, R. S. [1 ]
Komninakis, S. V. [1 ]
机构：
[1] Fed Univ Sao Paulo UNIFESP, Div Infect Dis, Retrovirol Lab, Sao Paulo, Brazil
[2] Lusiada Fdn Santos, Mol Biol Lab, Dept Med, Santos, Brazil
[3] Univ Sao Paulo, Div Clin Immunol & Allergy, Sao Paulo, Brazil
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
INTEGRASE INHIBITORS; GENETIC DIVERSITY; DRUG-RESISTANCE; NAIVE; SUBTYPES;
D O I：
10.1128/JCM.00539-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.
引用
收藏
页码：2122 / 2125
页数：4
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