Total synthesis of (+)-camptothecin via an intramolecular palladium-catalyzed cyclization strategy

被引：22

作者：

Chavan, Subhash P. ^{[1
]}

Pathak, Ashok B. ^{[1
]}

Kalkote, Uttam R. ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem Technol, Pune 411008, Maharashtra, India

来源：

SYNLETT | 2007年 / 17期

关键词：

natural products; alkaloids; antitumor; palladium; cyclizations;

D O I：

10.1055/s-2007-991054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel cascade intramolecular Pd-catalyzed cyclization followed by aromatization for the construction Of D ring of (+)-camptothecin as a key step is demonstrated.

引用

页码：2635 / 2638

页数：4

共 50 条

[1] Synthesis of Tetracyclic Flavonoids via Palladium-Catalyzed Intramolecular Oxidative Cyclization
Ayyagari, Narasimham
Belani, Jitendra D.
[J]. SYNLETT, 2014, 25 (16) : 2350 - 2354
[2] Indole synthesis via palladium-catalyzed intramolecular cyclization of alkynes and imines
Takeda, A
Kamijo, S
Yamamoto, Y
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (23) : 5662 - 5663
[3] Palladium-Catalyzed Synthesis of Dibenzophosphole Oxides via Intramolecular Dehydrogenative Cyclization
Kuninobu, Yoichiro
Yoshida, Takuya
Takai, Kazuhiko
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2011, 76 (18): : 7370 - 7376
[4] SYNTHESIS OF NITROGEN-HETEROCYCLES VIA PALLADIUM-CATALYZED INTRAMOLECULAR CYCLIZATION
LAROCK, RC
BABU, S
[J]. TETRAHEDRON LETTERS, 1987, 28 (44) : 5291 - 5294
[5] Palladium-Catalyzed Intramolecular Cyclization of Nitroalkenes: Synthesis of Thienopyrroles
El-Atawy, Mohamed A.
Ferretti, Francesco
Ragaini, Fabio
[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 2017 (14) : 1902 - 1910
[6] Synthesis of Polycyclic Sultams by Palladium-Catalyzed Intramolecular Cyclization
Majumdar, K. C.
Mondal, Shovan
De, Nirupam
[J]. SYNTHESIS-STUTTGART, 2009, (18): : 3127 - 3135
[7] First total synthesis of Dysidavarone A via an intramolecular palladium-catalyzed α-arylation
Schmalzbauer, Bjoern
Herrmann, Jennifer
Mueller, Rolf
Menche, Dirk
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
[8] Enantioselective synthesis of P-stereogenic benzophospholanes via palladium-catalyzed intramolecular cyclization
Brunker, Tim J.
Anderson, Brian J.
Blank, Natalia F.
Glueck, David S.
Rheingold, Arnold L.
[J]. ORGANIC LETTERS, 2007, 9 (06) : 1109 - 1112
[9] A Concise Total Synthesis of Steroid Scaffolds via a Palladium-Catalyzed Dearomatization Cyclization
Huang, Zhangwei
Pan, Xianhua
Guo, Lei
Tang, Wenjun
[J]. SYNLETT, 2022, 33 (17) : 1770 - 1774
[10] Palladium-catalyzed chemoselective intramolecular cyclization of bromoanilinoalkenenitriles
Yang, CC
Tai, HM
Sun, PJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (19): : 2843 - 2850

← 1 2 3 4 5 →