Wnt/β-catenin signaling promotes regeneration after adult zebrafish spinal cord injury

被引：66
|
作者：
Strand, Nicholas S. [1 ,2 ]
Hoi, Kimberly K. [1 ,2 ]
Phan, Tien M. T. [1 ,2 ]
Ray, Catherine A. [1 ,2 ]
Berndt, Jason D. [1 ,2 ]
Moon, Randall T. [1 ,2 ]
机构：
[1] Univ Washington, Sch Med, Dept Pharmacol, Howard Hughes Med Inst, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Inst Stem Cell & Regenerat Med, Seattle, WA 98195 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2016年 / 477卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Zebrafish; Regeneration; Wnt/beta-catenin signaling; Spinal cord injury;
D O I：
10.1016/j.bbrc.2016.07.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Unlike mammals, zebrafish can regenerate their injured spinal cord and regain control of caudal tissues. It was recently shown that Wnt/beta-catenin signaling is necessary for spinal cord regeneration in the larval zebrafish. However, the molecular mechanisms of regeneration may or may not be conserved between larval and adult zebrafish. To test this, we assessed the role of Wnt/beta-catenin signaling after spinal cord injury in the adult zebrafish. We show that Wnt/beta-catenin signaling is increased after spinal cord injury in the adult zebrafish. Moreover, overexpression of Dkk1b inhibited Wnt/beta-catenin signaling in the regenerating spinal cord of adult zebrafish. Dkk1b overexpression also inhibited locomotor recovery, axon regeneration, and glial bridge formation in the injured spinal cord. Thus, our data illustrate a conserved role for Wnt/beta-catenin signaling in adult and larval zebrafish spinal cord regeneration. Published by Elsevier Inc.
引用
收藏
页码：952 / 956
页数：5
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