Ligand-dependent stereoselective Suzuki-Miyaura cross-coupling reactions of β-enamido triflates

被引：5

作者：

Chvojka, Tomas ^{[1
]}

Markos, Athanasios ^{[1
,2
]}

Voltrova, Svatava ^{[1
]}

Pohl, Radek ^{[1
]}

Beier, Petr ^{[1
]}

机构：

[1] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Nam 2, Prague 16610, Czech Republic

[2] Charles Univ Prague, Fac Sci, Dept Organ Chem, Hlavova 2030-8, CZ-12843 Prague 2, Czech Republic

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 17卷

关键词：

enamides; isomerization; Suzuki-Miyaura coupling; vinyl triflates; HYDROAMIDATION; ISOMERIZATION; AMIDES;

D O I：

10.3762/bjoc.17.179

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective Suzuki-Miyaura cross-coupling of (Z)-beta-enamido triflates is demonstrated. Depending on the nature of the ligand in the palladium catalyst, either retention or inversion of the configuration during the synthesis of beta,beta-diaryl-substituted enamides is observed. Thus, the method provides synthetic access to both isomers of the target enamides from (Z)-beta-enamido triflates.

引用

页码：2657 / 2662

页数：6

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