Reinvestigation of Aminomethyltrifluoroborates and Their Application in Suzuki-Miyaura Cross-Coupling Reactions

被引：31
|
作者：
Raushel, Jessica [1 ]
Sandrock, Deidre L. [1 ]
Josyula, Kanth V. [2 ]
Pakyz, Deborah [2 ]
Molander, Gary A. [1 ]
机构：
[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA
[2] Sigma Aldrich New Prod, Milwaukee, WI 53209 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 08期
基金：
美国国家科学基金会;
关键词：
AMINOMETHYLATIONS; SCOPE;
D O I：
10.1021/jo2001066
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A reinvestigation into the chemical composition of potassium aminomethyltrifluoroborates is reported. These trifluoroborato salts have been reassigned as zwitterionic ammoniomethyltrifluoroborates. Minor adjustments to the previously disclosed reaction conditions are reported that permit a similar level of activity as nucleophiles in Suzuki-Miyaura cross-coupling reactions.
引用
收藏
页码：2762 / 2769
页数：8
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