The association of-656T>G and 1349T>G polymorphisms of ApE1 gene and the risk of female infertility

被引:1
|
作者
Mashayekhi, Farhad [1 ]
Yousefi, Mostafa [1 ]
Salehi, Zivar [1 ]
Pournourali, Mostafa [1 ]
机构
[1] Univ Guilan, Dept Biol, Fac Sci, Rasht, Iran
关键词
ApE1; female infertility; gene polymorphism; BER; ACID SUBSTITUTION VARIANTS; BASE-EXCISION-REPAIR; CANCER-RISK; DNA-DAMAGE; LUNG-CANCER; METAANALYSIS;
D O I
10.3109/01443615.2015.1127903
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Despite enormous progress in the understanding of human reproductive physiology, the underlying cause of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility. Human apurinic/apyrimidinic endonuclease 1 (ApE1) is a multifunctional protein that has an important role in the base excision repair pathway. The present study aimed to evaluate whether two functional ApE1 polymorphisms (-656T>G and 1349T>G) are associated with the susceptibility of female infertility. Blood samples were collected from 100 patients diagnosed with female infertility and 100 control subjects and genotyped by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). The results indicated that individuals with the variant TG genotypes had a significantly increased risk of female infertility (p=0.035, OR=1.98, 95% CI=1.04-3.74). Whereas, a significant association between 1349T>G polymorphism and female infertility risk was not observed (p=0.1). Larger studies with more patients and controls are required to confirm the results.
引用
收藏
页码:544 / 547
页数:4
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