Despite enormous progress in the understanding of human reproductive physiology, the underlying cause of male infertility remains undefined in about 50.0% of cases, which are referred to as idiopathic infertility. Human apurinic/apyrimidinic endonuclease 1 (ApE1) is a multifunctional protein that has an important role in the base excision repair pathway. The present study aimed to evaluate whether two functional ApE1 polymorphisms (-656T>G and 1349T>G) are associated with the susceptibility of female infertility. Blood samples were collected from 100 patients diagnosed with female infertility and 100 control subjects and genotyped by tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR). The results indicated that individuals with the variant TG genotypes had a significantly increased risk of female infertility (p=0.035, OR=1.98, 95% CI=1.04-3.74). Whereas, a significant association between 1349T>G polymorphism and female infertility risk was not observed (p=0.1). Larger studies with more patients and controls are required to confirm the results.
机构:
Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Han, L. Y.
Wu, Q. H.
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Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Wu, Q. H.
Jiao, M. L.
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Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Jiao, M. L.
Hao, Y. H.
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Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Hao, Y. H.
Liang, L. B.
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Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Liang, L. B.
Gao, L. J.
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Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Gao, L. J.
Legge, D. G.
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Univ Latrobe, Sch Publ Hlth, Dept Hlth Sci, Melbourne, Vic, AustraliaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Legge, D. G.
Quan, H.
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Univ Calgary, Dept Community Hlth Sci, Calgary, AB, CanadaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Quan, H.
Zhao, M. M.
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Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Zhao, M. M.
Ning, N.
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Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Ning, N.
Kang, Z.
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Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
Kang, Z.
Sun, H.
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Harbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R ChinaHarbin Med Coll, Sch Publ Hlth, Dept Social Med, Harbin 150081, Heilongjiang, Peoples R China
机构:
Univ Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, BR-97119900 Santa Maria, RS, Brazil
Univ Reg Integrada Alto Uruguai & Missoes, Dept Ciencias Biol, Santo Angelo, RS, BrazilUniv Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Escobar Piccoli, Jacqueline C.
Valle Gottlieb, Maria Gabriela
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Univ Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, BR-97119900 Santa Maria, RS, Brazil
Pontificia Univ Catolica Rio Grande do Sul, Fac Med, Serv Cardiol, Porto Alegre, RS, BrazilUniv Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Valle Gottlieb, Maria Gabriela
Castro, Luciano
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Pontificia Univ Catolica Rio Grande do Sul, Fac Educ Fis, Porto Alegre, RS, BrazilUniv Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Castro, Luciano
Bodanese, Luiz Carlos
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Pontificia Univ Catolica Rio Grande do Sul, Fac Med, Serv Cardiol, Porto Alegre, RS, BrazilUniv Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Bodanese, Luiz Carlos
Fernandes Manenti, Euler Roberto
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Pontificia Univ Catolica Rio Grande do Sul, Fac Med, Serv Cardiol, Porto Alegre, RS, BrazilUniv Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Fernandes Manenti, Euler Roberto
Bogo, Mauricio Reis
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Pontificia Univ Catolica Rio Grande do Sul, Ctr Biol Genom & Mol, Porto Alegre, RS, BrazilUniv Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Bogo, Mauricio Reis
Peres, Alessandra
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Ctr Univ IPA Metodista, Porto Alegre, RS, BrazilUniv Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Peres, Alessandra
da Rocha, Maria Izabel U. M.
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Univ Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, BR-97119900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
da Rocha, Maria Izabel U. M.
Manica da Cruz, Ivana Beatrice
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Univ Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, BR-97119900 Santa Maria, RS, BrazilUniv Fed Santa Maria, Lab Biogenom, Dept Morfol, Ctr Ciencias Saude, BR-97119900 Santa Maria, RS, Brazil
机构:
Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Med Oncol, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South KoreaYonsei Univ, Coll Med, Yonsei Canc Ctr, Canc Mat Res Ctr, Seoul 120752, South Korea
Rha, Sun Young
Jeung, Hei-Cheul
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Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Med Oncol, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South KoreaYonsei Univ, Coll Med, Yonsei Canc Ctr, Canc Mat Res Ctr, Seoul 120752, South Korea
Jeung, Hei-Cheul
Ahn, Loong Bae
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Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Med Oncol, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South KoreaYonsei Univ, Coll Med, Yonsei Canc Ctr, Canc Mat Res Ctr, Seoul 120752, South Korea
Ahn, Loong Bae
Jung, Jae Joon
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Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul 120752, South KoreaYonsei Univ, Coll Med, Yonsei Canc Ctr, Canc Mat Res Ctr, Seoul 120752, South Korea
Jung, Jae Joon
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Noh, Sung Hoon
Chung, Hyun Cheol
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Yonsei Univ, Coll Med, Yonsei Canc Ctr, Canc Mat Res Ctr, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Med Oncol, Seoul 120752, South Korea
Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South KoreaYonsei Univ, Coll Med, Yonsei Canc Ctr, Canc Mat Res Ctr, Seoul 120752, South Korea
机构:
CHA Univ, Sch Med, Dept Neurosurg, CHA Bundang Med Ctr, Songnam 463712, South KoreaCHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South Korea
Park, Young Seok
Jeon, Young Joo
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CHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South KoreaCHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South Korea
Jeon, Young Joo
Lee, Bo Eun
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CHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South KoreaCHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South Korea
Lee, Bo Eun
Kim, Tae Gon
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CHA Univ, Sch Med, Dept Neurosurg, CHA Bundang Med Ctr, Songnam 463712, South KoreaCHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South Korea
Kim, Tae Gon
Choi, Joong-Uhn
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CHA Univ, Sch Med, Dept Neurosurg, CHA Bundang Med Ctr, Songnam 463712, South KoreaCHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South Korea
Choi, Joong-Uhn
Kim, Dong-Seok
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Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Brain Res Inst,Dept Pediat Neurosurg,Severance Ho, Seoul, South KoreaCHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South Korea
Kim, Dong-Seok
Kim, Nam Keun
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CHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South KoreaCHA Univ, Sch Med, Inst Clin Res, CHA Bundang Med Ctr, Songnam 463712, South Korea