Chemical composition and cytotoxic activity of the essential oil from the leaves of Casearia lasiophylla

被引：25
|
作者：
Salvador, Marcos Jose [1 ]
de Carvalho, Joao Ernesto [2 ]
Wisniewski-, Alberto, Jr. [3 ]
Kassuya, Candida A. L. [4 ]
Santos, Elide P. [5 ]
Riva, Dilamara [6 ]
Alves Stefanello, Maria Elida [6 ]
机构：
[1] Univ Estadual Campinas, Curso Farm, Dept Biol Vegetal, Inst Biol, BR-13083970 Campinas, SP, Brazil
[2] Univ Estadual Campinas, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, BR-13083970 Campinas, SP, Brazil
[3] Univ Fed Sergipe, Dept Quim, Sergipe, Brazil
[4] Fundacao Univ Fed Grande Dourados, Fac Ciencias Saude, Mato Grosso, Brazil
[5] Univ Fed Parana, Dept Bot, BR-80060000 Curitiba, Parana, Brazil
[6] Univ Fed Parana, Dept Quim, BR-80060000 Curitiba, Parana, Brazil
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2011年 / 21卷 / 05期
基金：
巴西圣保罗研究基金会;
关键词：
Casearia lasiophylla; Salicaceae; essential oil; germacrene D; beta-caryophyllene; antitumor; CLERODANE DITERPENES; ANTIULCER;
D O I：
10.1590/S0102-695X2011005000073
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The essential oil obtained by hydrodistillation from fresh leaves of Casearia lasiophylla Eichler, Salicaceae, was analyzed by gas capillary (GC/FID and GC/MS). The cytotoxicity of the leaves essential oil was tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), NCI-H460 (lung), PC03 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The yield of oil was 0.02%. Fifty two compounds were identified, representing 87.1% of the total of the oil. The main components were identified as germacrene D (18.6%), beta-caryophyllene (14.7%), delta-cadinene (6.2%), and alpha-cadinol (5.4%). The oil exhibited antiproliferative activity against all cell lines (TGI<100 mu g/mL), with exception of NCI-H460 cell line (TGI 191.31. mu g/mL). The highest activity was observed against UACC-62 (TGI 7.30 mu g/mL), and K562 (TGI 7.56 mu g/mL) cell lines. The observed activity could be related to high content of germacrene D and. beta-caryophyllene, compounds known as cytotoxic.
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页码：864 / 868
页数：5
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