Two new isoflavones from the seeds of Psoralea corylifolia with diacylglycerol acyltransferase inhibitory activity

被引：3
|
作者：
Wang, Cui-Yun [1 ]
Ai, Guang-Feng [1 ,2 ]
Zhang, Ya-Fei [1 ]
机构：
[1] 1 People's Hosp, Dept Pharm, Jining, Jining, Peoples R China
[2] 1 People's Hosp, Dept Pharm,CONTACT Guang,Feng,Jining, Jining, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 04期
关键词：
Leguminosae; Psoralea corylifolia; isoflavones; diabetes; DGAT; IDENTIFICATION; METABOLITES; FRUITS;
D O I：
10.1080/10286020.2019.1570159
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new compounds 7-hydroxy-4'-methoxy-3'-(7''-hydroxy-3'',7''-dimethyl-octa-2'',5''-dienyl)-isoflavone (1) and 7-hydroxy-4'-methoxy-3'-(6''-hydroxy-3'',7''-dimethyl-octa-2'',7''-dienyl)-isoflavone (2), together with five known compounds (3-7), were isolated from EtOAc-soluble extract of the seeds of Psoralea corylifolia. Their structures were elucidated on the basis of detailed spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against diacylglycerol acyltransferase (DGAT). And compounds 1-7 displayed significant inhibitory activity on DGAT1 with IC50 values ranging from 51.2 +/- 1.1 to 116.4 +/- 1.3 mu M.
引用
收藏
页码：346 / 352
页数：7
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