Synthetic studies of 14-membered cyclopeptide alkaloids

被引：19
|
作者：
East, SP [1 ]
Joullie, MM [1 ]
机构：
[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 40期
关键词：
D O I：
10.1016/S0040-4039(98)01589-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A strained 14-membered cyclopeptide was prepared from the Garner aldehyde derived from D-serine. The key steps in the synthesis were the construction of the alkyl-aryl ether linkage via an SNAr reaction involving 4-fluorobenzonitrile and the macrolactamization using a modification of the Schmidt protocol involving an activated pentafluorophenyl ester. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：7211 / 7214
页数：4
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