New 14-Membered Cyclopeptide Alkaloids from Zizyphus oxyphylla Edgew

被引：17

作者：

Kaleem, Waqar Ahmad ^{[2
]}

Nisar, Muhammad ^{[3
]}

Qayum, Mughal ^{[4
]}

Zia-Ul-Haq, Muhammad ^{[5
]}

Adhikari, Achyut ^{[6
]}

De Feo, Vincenzo ^{[1
]}

机构：

[1] Univ Salerno, Dept Pharmaceut & Biomed Sci, I-84100 Salerno, Italy

[2] Abdul Wali Khan Univ Mardan, Dept Pharm, Mardan 23200, Pakistan

[3] Univ Peshawar, Inst Chem Sci, Peshawar 25120, Pakistan

[4] Kohat Univ Sci & Technol, Inst Pharmaceut Sci, Kohat 2600, Pakistan

[5] Univ Karachi, Pharmaceut Sci Res Inst, Dept Pharmacognosy, Karachi 75270, Pakistan

[6] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 09期

关键词：

Zizyphus oxyphylla Edgew; cyclopeptide alkaloids; antibacterial activity; ANTIBACTERIAL ACTIVITIES; PEPTIDE ALKALOIDS; ANTIFUNGAL; LEAVES;

D O I：

10.3390/ijms130911520

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 mu g/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 mu g/mL), Pseudomonas aeruginosa (MIC, 50 mu g/mL) and Salmonella typhi (MIC, 50 mu g/mL).

引用

页码：11520 / 11529

页数：10

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