Demonstration of systemic antitumor immunity via intratumoral regulated expression of IL-12 as a gene therapy approach to treatment of cancer

被引：0
|
作者：
Barrett, John A. [1 ]
Chan, Tim [2 ]
Cai, Hongliang [1 ]
Miao, John [1 ]
Krishnan, Suma [2 ]
Lebel, Francois [1 ]
机构：
[1] Ziopharm Oncol, Boston, MA USA
[2] Intrexon, Germantown, MD USA
来源：
CANCER IMMUNOLOGY RESEARCH | 2016年 / 4卷 / 01期
关键词：
D O I：
10.1158/2326-6074.CRICIMTEATIAACR15-B091
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
B091
引用
收藏
页数：2
相关论文
共 50 条
  • [21] IL-12 gene therapy for cancer: in synergy with other immunotherapies
    Melero, I
    Mazzolini, G
    Narvaiza, I
    Qian, C
    Chen, LP
    Prieto, J
    TRENDS IN IMMUNOLOGY, 2001, 22 (03) : 113 - 115
  • [22] Combined direct intratumoral adenoviral delivery and production of Rheoswitch®-regulated IL-12 and IFNα enhances antitumor activity in lung and breast cancer models
    Murugesan, Selva
    Chan, Tim
    Reed, Charles
    Bharathan, Mini
    Connelly, Sheila
    Fogler, William E.
    Youssoufian, Hagop
    Herberman, Ron
    CANCER RESEARCH, 2012, 72
  • [23] CONTROLLED LOCAL EXPRESSION OF IL-12 AS GENE THERAPY CONCOMITANT WITH SYSTEMIC CHEMOTHERAPY IMPROVES SURVIVAL IN GLIOMA
    Barrett, John
    Cai, Hongliang
    Miao, John
    Khare, Pranay
    Dalsing-Hernandez, Jessica
    Gonzales, Paul
    Chan, Tim
    Cooper, Laurence
    Lebel, Francois
    NEURO-ONCOLOGY, 2017, 19 : 119 - 120
  • [24] Production of IL-12 from gene modified human dermal fibroblasts: A preclinical study for IL-12 cancer gene therapy
    Chaehwa Park
    Won-Ki Kang
    Misook Oh
    Won Seog Kim
    Jung-Hyun Yang
    Michael T Lotze
    Sunyoung Kim
    Keunchil Park
    Chan H Park
    Experimental & Molecular Medicine, 1997, 29 : 65 - 69
  • [25] Treatment of spontaneous canine mast cell tumors by electrochemotherapy combined with IL-12 gene electrotransfer: Comparison of intratumoral and peritumoral application of IL-12
    Tratar, Ursa Lampreht
    Milevoj, Nina
    Cemazar, Maja
    Znidar, Katarina
    Valentinuzzi, Katja Ursic
    Brozic, Andreja
    Tomsic, Katerina
    Sersa, Gregor
    Tozon, Natasa
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 120
  • [26] Production of IL-12 from gene modified human dermal fibroblasts: A preclinical study for IL-12 cancer gene therapy
    Park, C
    Kang, WK
    Oh, M
    Kim, WS
    Yang, JH
    Lotze, MT
    Kim, S
    Park, K
    Park, CH
    EXPERIMENTAL AND MOLECULAR MEDICINE, 1997, 29 (01): : 65 - 69
  • [27] Intratumoral Gene Transfer of mRNAs Encoding IL12 in Combination with Decoy-Resistant IL18 Improves Local and Systemic Antitumor Immunity
    Cirella, Assunta
    Bolanos, Elixabet
    Di Trani, Claudia Augusta
    de Andrea, Carlos E.
    Sanchez-Gregorio, Sandra
    Etxeberria, Inaki
    Gonzalez-Gomariz, Jose
    Olivera, Irene
    Brocco, Davide
    Glez-Vaz, Javier
    Luri-Rey, Carlos
    Azpilikueta, Arantza
    Rodriguez, Inmaculada
    Fernandez-Sendin, Myriam
    Egea, Josune
    Eguren, Inaki
    Sanmamed, Miguel F.
    Palencia, Belen
    Teijeira, Alvaro
    Berraondo, Pedro
    Melero, Ignacio
    CANCER IMMUNOLOGY RESEARCH, 2023, 11 (02) : 184 - 198
  • [28] Intravesical Treatment of Orthotopic Bladder Cancer With Chitosan/IL-12 Induces Systemic Tumor-Specific Immunity
    Smith, Sean G.
    Yang, Lirong
    Zaharoff, David
    JOURNAL OF IMMUNOTHERAPY, 2012, 35 (09) : 734 - 734
  • [29] Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12
    Tannenbaum, CS
    Wicker, N
    Armstrong, D
    Tubbs, R
    Finke, J
    Bukowski, RM
    Hamilton, TA
    JOURNAL OF IMMUNOLOGY, 1996, 156 (02): : 693 - 699
  • [30] Impaired production of IL-12 in systemic lupus erythematosus.: III:: Deficient IL-12 p40 gene expression and cross-regulation of IL-12, IL-10 and IFN-γ gene expression
    Liu, TF
    Jones, BM
    Wong, RWS
    Srivastava, G
    CYTOKINE, 1999, 11 (10) : 805 - 811
12345