Adjustments of γδ T Cells in the Lung of Schistosoma japonicum-Infected C56BL/6 Mice

被引:8
|
作者
Cha, Hefei [1 ]
Xie, Hongyan [1 ]
Jin, Chenxi [1 ]
Feng, Yuanfa [1 ]
Xie, Shihao [1 ]
Xie, Anqi [1 ]
Yang, Quan [1 ]
Qi, Yanwei [1 ]
Qiu, Huaina [1 ]
Wu, Qiongli [2 ]
Yin, Zhinan [3 ]
Mu, Jianbing [4 ]
Huang, Jun [1 ]
机构
[1] Guangzhou Med Univ, Affiliated Hosp 2, Sino French Hoffmann Inst, Guangdong Prov Key Lab Allergy & Clin Immunol, Guangzhou, Peoples R China
[2] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Immunol, Guangzhou, Peoples R China
[3] Jinan Univ, Sch Pharm, Biomed Translat Res Inst, Guangzhou, Peoples R China
[4] NIAID, Lab Malaria & Vector Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
来源
FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷
关键词
Schistosoma japonicum; lung; gamma delta T cells; phenotype; function;
D O I
10.3389/fimmu.2020.01045
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Many kinds of lymphocytes are involved in Schistosoma japonicum (S. japonicum) infection-induced disease. gamma delta T cells comprise a small number of innate lymphocytes that quickly respond to foreign materials. In this study, the role of gamma delta T cells in the lung of S. japonicum-infected C56BU6 mice was investigated. The results demonstrated that S. japonicum infection induces gamma delta T cell accumulation in the lung, expressing higher levels of CD25, MHCII, CD80, and PDL1, and lower levels of CD127 and CD62L (P < 0.05). The intracellular cytokines staining results illustrated higher percentages of IL-4-, IL-10-, IL-21-, and IL-6-producing gamma delta T cells and lower percentages of IFN-gamma-expressing gamma delta T cells in the lung of infected mice (P < 0.05). Moreover, the granuloma size in lung tissue was significantly increased in V delta(-/-) mice (P < 0.05). In the lung of S. japonicum-infected V delta(-/-) mice, both type 1 and type 2 immune responses were decreased significantly (P < 0.05). In addition, the expression of CD80 and CD69 on B cells was decreased significantly (P < 0.05), and the SEA-specific antibody was markedly decreased (P < 0.05) in the blood of infected V delta(-/-) mice. In conclusion, this study indicates that gamma delta T cells could adjust the Th2 dominant immune response in the lung of S. japonicum-infected mice.
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页数:13
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