Two new troponoides with anti-inflammatory activity from the stems of Juniperus formosana Hayata

被引：2

作者：

Zheng, Dong ^{[1
]}

Zhang, Jian-Yu ^{[2
]}

Fu, Wen-Hao ^{[2
]}

Liu, Shun-Zhi ^{[2
]}

Xie, Su-Zhi ^{[3
]}

Wang, Zheng ^{[4
]}

Qiu, Ying-Kun ^{[2
]}

机构：

[1] Xiamen Hosp Tradit Chinese Med, Dept Pharm, Xiamen, Peoples R China

[2] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen, Peoples R China

[3] Xiamen Haicang Hosp, Dept Pharm, Xiamen, Peoples R China

[4] Xiamen Univ, Dept Pharm, Zhongshan Hosp, Xiamen, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 23期

关键词：

Juniperus formosana Hayata; troponoides; anti-inflammatory activity; SESQUITERPENES; HEARTWOOD;

D O I：

10.1080/14786419.2020.1741584

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new troponoides (1-2) were isolated from a 95% ethanol extract of the stems of Juniperus formosana (Cupressaceae), together with six known compounds (3-8). The structures of the new compounds were comprehensively characterized by high resolution electrospray ionization-mass spectrometry (HR-ESI-MS), 1D and 2D nuclear magnetic resonance (NMR). Compounds 1-7 were evaluated for their anti-inflammatory against the expression of IL-1 beta, IL-6 and TNF-alpha in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. The new compounds showed moderate anti-inflammatory effect, while other compounds did show no activity.

引用

页码：4901 / 4906

页数：6

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