Two new troponoides with anti-inflammatory activity from the stems of Juniperus formosana Hayata

被引：2
|
作者：
Zheng, Dong [1 ]
Zhang, Jian-Yu [2 ]
Fu, Wen-Hao [2 ]
Liu, Shun-Zhi [2 ]
Xie, Su-Zhi [3 ]
Wang, Zheng [4 ]
Qiu, Ying-Kun [2 ]
机构：
[1] Xiamen Hosp Tradit Chinese Med, Dept Pharm, Xiamen, Peoples R China
[2] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen, Peoples R China
[3] Xiamen Haicang Hosp, Dept Pharm, Xiamen, Peoples R China
[4] Xiamen Univ, Dept Pharm, Zhongshan Hosp, Xiamen, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 23期
关键词：
Juniperus formosana Hayata; troponoides; anti-inflammatory activity; SESQUITERPENES; HEARTWOOD;
D O I：
10.1080/14786419.2020.1741584
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new troponoides (1-2) were isolated from a 95% ethanol extract of the stems of Juniperus formosana (Cupressaceae), together with six known compounds (3-8). The structures of the new compounds were comprehensively characterized by high resolution electrospray ionization-mass spectrometry (HR-ESI-MS), 1D and 2D nuclear magnetic resonance (NMR). Compounds 1-7 were evaluated for their anti-inflammatory against the expression of IL-1 beta, IL-6 and TNF-alpha in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. The new compounds showed moderate anti-inflammatory effect, while other compounds did show no activity.
引用
收藏
页码：4901 / 4906
页数：6
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