Successful Treatment of Antifungal Combination Therapy with Inhaled Liposomal Amphotericin B and Oral Voriconazole for Intractable Chronic Progressive Pulmonary Aspergillosis

被引：0

作者：

Hamada, Noboru ^{[1
]}

Ishiga, Mitsunori ^{[2
]}

Tanaka, Suzuka ^{[1
]}

Ooue, Yasuhiro ^{[2
]}

Itano, Junko ^{[3
]}

Tanaka, Hisaaki ^{[2
]}

Yuzurio, Shota ^{[1
]}

Horiuchi, Takeshi ^{[1
]}

Suwaki, Toshimitsu ^{[1
]}

Kimura, Goro ^{[2
]}

Tanimoto, Yasushi ^{[2
]}

机构：

[1] Okayama City Hosp, Dept Resp Med, Okayama, Japan

[2] Minami Okayama Med Ctr, Natl Hosp Org, Dept Allergy & Resp Med, Okayama, Japan

[3] Okayama Univ Hosp, Dept Allergy & Resp Med, Okayama, Japan

来源：

INTERNAL MEDICINE | 2021年 / 60卷 / 15期

关键词：

chronic progressive pulmonary aspergillosis; fungus ball; inhaled liposomal amphotericin B; antifungal combination therapy; Aspergillus niger; INVASIVE ASPERGILLOSIS; EFFICACY; OUTCOMES;

D O I：

10.2169/internalmedicine.6.305-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We experienced a case of the successful treatment of intractable pulmonary aspergillosis with inhaled liposomal amphotericin B (L-AMB) and oral voriconazole (VRCZ). A 52-year-old man was admitted to our hospital with a fever. Chest computed tomography (CT) revealed an infiltrative shadow. Two separate sputum cultures detected Aspergillus niger. Although we treated the patient with single and combined antifungal agents, the infiltrative shadow worsened. After obtaining sufficient informed consent from the patient, we switched him to an inhaled L-AMB. The infiltrative shadow subsequently improved. The patient has remained well for one year without exacerbation. We herein report the usefulness of inhaled L-AMB and oral VRCZ.

引用

页码：2465 / 2468

页数：4

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