Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine

被引：7

作者：

Sun, YongMei ^{[1
,2
]}

Zong, Wei ^{[1
]}

Zhou, MuRu ^{[3
]}

Ma, YuanYe ^{[1
]}

Wang, JianHong ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Kunming 650223, Peoples R China

[2] Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogen & Cognit Res, NL-1081 HV Amsterdam, Netherlands

[3] Fudan Univ, Sch Pharm, Shanghai 200433, Peoples R China

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2015年 / 135卷

关键词：

Morphine; Chloral hydrate; Rewarding effect; Conditioned place preference; MIDBRAIN DOPAMINE NEURONS; ANESTHETIZED RATS; ADDICTION; ANESTHESIA; PARADIGM; SEDATION; MEMORY; DRUGS;

D O I：

10.1016/j.pbb.2015.05.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The medical use of morphine as a pain killer is hindered by its side effects including dependence and further addiction. As the prototypical mu receptor agonist, morphine's rewarding effect can be measured by conditioned place preference (CPP) paradigms in animals. Chloral hydrate is a clinical sedative. Using a morphine CPP paradigm that mainly contains somatosensory cues, we found that pre-CPP treatment in rats using chloral hydrate for 6 consecutive days could disrupt the establishment of CPP in a U shape. Chloral hydrate had no effect on the body weight of rats. Our results indicate that prior treatment with chloral hydrate can interrupt the rewarding effect of morphine. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：60 / 63

页数：4

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