Population pharmacokinetics of micafungin in adult patients

被引：60
|
作者：
Gumbo, Tawanda [1 ]
Hiemenz, John [2 ]
Ma, Lei [1 ]
Keirns, James J. [3 ]
Buell, Donald N. [3 ]
Drusano, George L. [1 ]
机构：
[1] Ordway Res Inst, Albany, NY 12208 USA
[2] Feist Weiller Canc Ctr, Shreveport, LA 71130 USA
[3] Astellas Pharma USA Inc, Deerfield, IL 60015 USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2008年 / 60卷 / 03期
关键词：
micafungin; population pharmacokinetics;
D O I：
10.1016/j.diagmicrobio.2007.09.018
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We performed population pharmacokinetic analysis of micafungin in adult patients treated with doses between 12.5 and 200 mg/day. Our analysis identified a breakpoint patient weight of 66.3 kg above which serum clearance increased by approximately 50%. Patients with weight >66.3 kg may need larger doses to achieve similar exposures to those <66.3 kg. However, the clinical implications are still unknown. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：329 / 331
页数：3
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