Population pharmacokinetics of micafungin in adult patients

被引：61

作者：

Gumbo, Tawanda ^{[1
]}

Hiemenz, John ^{[2
]}

Ma, Lei ^{[1
]}

Keirns, James J. ^{[3
]}

Buell, Donald N. ^{[3
]}

Drusano, George L. ^{[1
]}

机构：

[1] Ordway Res Inst, Albany, NY 12208 USA

[2] Feist Weiller Canc Ctr, Shreveport, LA 71130 USA

[3] Astellas Pharma USA Inc, Deerfield, IL 60015 USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2008年 / 60卷 / 03期

关键词：

micafungin; population pharmacokinetics;

D O I：

10.1016/j.diagmicrobio.2007.09.018

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We performed population pharmacokinetic analysis of micafungin in adult patients treated with doses between 12.5 and 200 mg/day. Our analysis identified a breakpoint patient weight of 66.3 kg above which serum clearance increased by approximately 50%. Patients with weight >66.3 kg may need larger doses to achieve similar exposures to those <66.3 kg. However, the clinical implications are still unknown. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：329 / 331

页数：3

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