No selection for CCR5 coreceptor usage during parenteral transmission of macrophagetropic syncytium-inducing human immunodeficiency virus type 1

被引：9
|
作者：
Koning, FA
Schols, D
Schuitemaker, H
机构：
[1] CLB Sanquin, Dept Clin Viroimmunol, NL-1066 CX Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Expt & Clin Immunol Lab, NL-1105 AZ Amsterdam, Netherlands
[3] Katholieke Univ Leuven, Rega Inst, Lab Virol & Chemotherapy, B-3000 Louvain, Belgium
来源：
JOURNAL OF VIROLOGY | 2001年 / 75卷 / 18期
关键词：
D O I：
10.1128/JVI.75.18.8848-8853.2001
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In two cases of parenteral transmission of human immunodeficiency virus type 1 (HIV-1) syncitium-inducing (SI) variants, we previously observed selection for macrophagetropic variants. Although infection of macrophages is generally mediated via CCR5, we found no selection for SI variants that could use CCR5 as coreceptor in addition to CXCR4, suggesting that features other than coreceptor usage account for the macrophagetropism of these transmitted SI HIV-1 variants.
引用
收藏
页码：8848 / 8853
页数：6
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