Serum leptin concentration in cord blood: Relationship to birth weight and gender

被引:220
|
作者
Matsuda, J [1 ]
Yokota, I [1 ]
Iida, M [1 ]
Murakami, T [1 ]
Naito, E [1 ]
Ito, M [1 ]
Shima, K [1 ]
Kuroda, Y [1 ]
机构
[1] UNIV TOKUSHIMA, SCH MED, DEPT LAB MED, TOKUSHIMA 770, JAPAN
来源
关键词
D O I
10.1210/jc.82.5.1642
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To investigate the effect of leptin on fetal growth, serum leptin concentrations in venous cord blood were measured in 82 newborns (male = 43, female = 39, gestational age 36-42 weeks, birth weight 2,306-4,128 g). Serum leptin concentrations in cord blood ranged from 2.0 to 84.5 ng/mL (mean 19.9 +/- 17.4 ng/mL). Serum leptin concentrations in males (mean 15.3 +/- 15.6 ng/mL, range 2.0 to 79.3 ng/mL)) were significantly (P = 0.011) lower than those in females (mean 25.0 +/- 18.0 ng/mL, range 2.1 to 84.5 ng/mL). Serum leptin concentrations in cord blood were positively correlated with birth weight (r = 0.555, P <0.0001), birth weight SD (r = 0.540, P <0.0001), Kaup index (r = 0.505, P <0.0001) and body weight/body height (r = 0.560, P <0.0001). The serum concentrations of estradiol and testosterone did not differ between males and females and did not correlate with the leptin concentration. It is unlikely that the gender difference in fetal leptin levels is due either to body fat content or distribution or to reproductive hormone status, but may be attributed to genetic differences between males and females.
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收藏
页码:1642 / 1644
页数:3
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