Tumor-Infiltrating Lymphocytes: A Promising Biomarker in Breast Cancer

被引：30

作者：

Heppner, Barbara Ingold ^{[1
]}

Loibl, Sibylle ^{[2
,3
]}

Denkert, Carsten ^{[1
,4
]}

机构：

[1] Charite, Inst Pathol, D-13353 Berlin, Germany

[2] German Breast Grp GBG Forsch GmbH, Neu Isenburg, Germany

[3] Sana Klinikum Offenbach, Offenbach, Germany

[4] German Canc Consortium DKTK, Berlin, Germany

来源：

BREAST CARE | 2016年 / 11卷 / 02期

关键词：

Breast cancer; Tumor-infiltrating lymphocytes; Adjuvant; Neoadjuvant; Pathological complete response; NEOADJUVANT CHEMOTHERAPY; PROGNOSTIC VALUE; PREDICTIVE-VALUE; PRIMARY THERAPY; TRASTUZUMAB; CARCINOMA; CONSENSUS; ANTIBODY;

D O I：

10.1159/000444357

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is clear evidence that the immune system plays an essential role in tumor defense. By determining tumor-infiltrating lymphocytes (TILs), the individual immunological response becomes more apparent and measurable. In breast cancer, high levels of TILs are associated with a more favorable clinical course. In this review, we describe how TILs are determined with emphasis on daily routine diagnostics. We further discuss their impact as a prognostic and predictive biomarker in the neoadjuvant and adjuvant therapy setting as well as in residual disease. We also discuss their potential future implications on further stratifying prognostic subgroups of breast cancer, thereby possibly influencing future therapy considerations. (C) 2016 S. Karger GmbH, Freiburg

引用

页码：96 / 100

页数：5

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