Microneedles for transdermal delivery of insulin

被引：39

作者：

Xie, Song ^{[1
]}

Li, Zijing ^{[2
]}

Yu, Zongqin ^{[2
]}

机构：

[1] Shandong Univ, Shandong Prov Hosp, Dept Pharm, Jinan 250021, Shandong, Peoples R China

[2] Shandong Med Coll, Dept Pharmacol & Pharmaceut Sci, Linyi 250012, Shandong, Peoples R China

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2015年 / 28卷

关键词：

Microneedles; Insulin; Transdermal drug delivery; Diabetes; Permeability; DRUG-DELIVERY; POLYMER MICRONEEDLES; HOLLOW MICRONEEDLES; ORAL DELIVERY; IN-VIVO; METAL MICRONEEDLES; SUSTAINED-RELEASE; DIABETIC-RATS; PROTEIN DRUGS; ARRAYS;

D O I：

10.1016/j.jddst.2015.04.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Insulin medication is currently effective in the treatment of type I diabetes. Due to the poor absorption or enzymatic degradation of insulin in the gastrointestinal tract and liver, the subcutaneous route has been so far the preferred method of insulin administration. However, this route is associated with poor patient compliance due to the pain caused by injection and risk of inflammation and infection. Microneedles (MNs) have been widely studied for transdermal delivery of insulin as minimally invasive and painless in human subjects. This review article focuses on recent and emerging progress in MN technologies utilized for the transdermal delivery of insulin. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：11 / 17

页数：7

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