Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer

被引：515
|
作者：
Cao, Haiqiang [1 ,2 ,3 ]
Dan, Zhaoling [1 ,2 ]
He, Xinyu [1 ,2 ,3 ]
Zhang, Zhiwen [1 ,2 ]
Yu, Haijun [1 ,2 ]
Yin, Qi [1 ,2 ]
Li, Yaping [1 ,2 ]
机构：
[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[2] Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ACS NANO | 2016年 / 10卷 / 08期
基金：
中国国家自然科学基金;
关键词：
macrophage; liposome; drug delivery; metastasis; breast cancer; MICROENVIRONMENTAL REGULATION; POLYMERIC NANOPARTICLES; TUMOR PENETRATION; DRUG-DELIVERY; THERAPY; VCAM-1; PROGRESSION; PLATFORM; BIOLOGY; GROWTH;
D O I：
10.1021/acsnano.6b03148
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cancer metastasis leads to high mortality of breast cancer and is difficult to treat because of the poor delivery efficiency of drugs. Herein, we report the wrapping of a drug-carrying liposome with an isolated macrophage membrane to improve delivery to metastatic sites. The macrophage membrane decoration increased cellular uptake of the emtansine liposome in metastatic 4T1 breast cancer cells and had inhibitory effects on cell viability. In vivo, the macrophage membrane enabled the liposome to target metastatic cells and produced a notable inhibitory effect on lung metastasis of breast cancer. Our results provide a biomimetic strategy via the biological properties of macrophages to enhance the medical performance of a nanoparticle in vivo for treating cancer metastasis.
引用
收藏
页码：7738 / 7748
页数：11
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