Variational image registration by a total fractional-order variation model

In this paper, a new framework of nonlocal deformation in non-rigid image registration is presented. It is well known that many non-rigid image registration techniques may lead to unsteady deformation (e.g. not one to one) if the dissimilarity between the reference and template images is too large. We present a novel variational framework of the total fractional-order variation to derive the underlying fractional Euler-Lagrange equations and a numerical implementation combining the semi-implicit update and conjugate gradients (CG) solution to solve the nonlinear systems. Numerical experiments show that the new registration not only produces accurate and smooth solutions but also allows for a large rigid alignment, the evaluations of the new model demonstrate substantial improvements in accuracy and robustness over the conventional image registration approaches. (C) 2015 Elsevier Inc. All rights reserved.