Quinolin-8-yloxy-substituted zinc(II) phthalocyanines for enhanced in vitro photodynamic therapy

被引：6
|
作者：
Chen, Juanjuan [1 ,2 ]
Fang, Yuting [1 ,2 ]
Liu, Hong [1 ,2 ]
Chen, Naisheng [1 ,2 ]
Chen, Shengping [3 ]
Xue, Jinping [1 ,2 ]
机构：
[1] Fuzhou Univ, Coll Chem, Natl & Local Joint Biomed Engn Res Ctr Photodynam, Fuzhou 350116, Fujian, Peoples R China
[2] Fuzhou Univ, Coll Chem, Fujian Engn Res Ctr Photodynam Therapy & Diagnose, Fuzhou 350116, Fujian, Peoples R China
[3] Fuzhou Gen Hosp, PLA, Dermatol Dept, Fuzhou 350025, Fujian, Peoples R China
来源：
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES | 2018年 / 22卷 / 9-10期
基金：
中国国家自然科学基金;
关键词：
phthalocyanine; photodynamic therapy; quinolin-8-yloxy; PHOTOSENSITIZERS; QUINOLINE; TARGET; DRUG; MECHANISMS; SYSTEMS; OXYGEN;
D O I：
10.1142/S1088424618500669
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Photodynamic therapy (PDT) is an innovative and promising modality to treat various tumors. In this study, two novel zinc(II) phthalocyanines substituted with quinolin-8-yloxy groups at the a-position, namely mono(quinolin-8-yloxy) zinc(II) phthalocyanine (ZnPc-Q1) and tetra(quinolin8- yloxy) zinc(II) phthalocyanine (ZnPc-Q4), have been synthesized and fully characterized. With quinolin-8-yloxy, these two phthalocyanines exhibit less self-aggregation in DMF and culture medium, high singlet oxygen quantum yields, mitochondria localization and high photodynamic activities (IC50 values as low as 2 nM). Compared to ZnPc-Q4, ZnPc-Q1 exhibits higher cellular uptake and lower IC50 values. Benefitting from its higher anticancer efficacy and lack of isomers, ZnPc-Q1 is a highly promising anticancer agent in clinical application.
引用
收藏
页码：807 / 813
页数：7
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