Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation

被引：37
|
作者：
Patil, S. U. [1 ]
Shreffler, W. G. [1 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Boston, MA 02114 USA
来源：
CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 167卷 / 01期
关键词：
basophil; desensitization; immunotherapy; FC-EPSILON-RI; GRASS-POLLEN IMMUNOTHERAPY; WASP VENOM ALLERGY; HISTAMINE-RELEASE; IMMUNOGLOBULIN-G; ACTIVATION MARKERS; MAST-CELL; IGE; SENSITIVITY; EXPRESSION;
D O I：
10.1111/j.1365-2249.2011.04503.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Allergen-specific immunotherapy is an effective clinical treatment for hypersensitivity to many allergens. Studies of basophils during immunotherapy have provided insight into underlying immune mechanisms and support the potential use of basophil activation as a biomarker of clinical outcomes. This review examines the evidence for different pathways of basophil modulation associated with various forms of immunotherapy. Better understanding the molecular mechanisms of basophil activation and desensitization and the relationship between suppression of these effector cells to clinical outcomes holds promise for further development and improvement in potential therapies for allergic diseases.
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收藏
页码：59 / 66
页数：8
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