Immunology in the clinic review series; focus on cancer: glycolipids as targets for tumour immunotherapy

被引：47

作者：

Durrant, L. G. ^{[1
]}

Noble, P. ^{[1
]}

Spendlove, I. ^{[1
]}

机构：

[1] Univ Nottingham, City Hosp, Acad Dept Clin Oncol, Nottingham NG5 1PB, England

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 167卷 / 02期

关键词：

cancer vaccine; glycolipid; glycosylation; immunotherapy; monoclonal antibody; CELL-LUNG-CANCER; ALPHA-5-BETA-1 INTEGRIN RECEPTOR; MOUSE MONOCLONAL-ANTIBODIES; N-GLYCOLYLNEURAMINIC ACID; HUMAN BREAST-CANCER; SIALYL-LEWIS-X; GM3; GANGLIOSIDE; MELANOMA PATIENTS; CONJUGATE VACCINE; ADJUVANT VACCINATION;

D O I：

10.1111/j.1365-2249.2011.04516.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Research into aberrant glycosylation and over-expression of glycolipids on the surface of the majority of cancers, coupled with a knowledge of glycolipids as functional molecules involved in a number of cellular physiological pathways, has provided a novel area of targets for cancer immunotherapy. This has resulted in the development of a number of vaccines and monoclonal antibodies that are showing promising results in recent clinical trials.

引用

页码：206 / 215

页数：10

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