Objective: Cognitive-behavioral therapy has proven to be highly effective in the treatment of hypochondriasis and health anxiety. However, little is known about which therapeutic interventions are most promising. The aim of the present study was to compare the efficacy of cognitive therapy (CT) with exposure therapy (ET). Method: Eighty-four patients with a diagnosis of hypochondriasis were randomly allocated to CT, ET, or a waiting list (WL) control group. The primary outcome measure was a standardized interview that evaluated hypochondriacal cognitions as well as behaviors conducted by independent diagnosticians. Several self-report questionnaires were evaluated as secondary outcome measures. Treatment success was evaluated at posttreatment and at 1-year follow-up. Results: Both CT (Hedges's g = 1.01-1.11) and ET (Hedges's g = 1.21-1.24) demonstrated their efficacy in comparison with the WL in the primary outcome measure. Moreover, a significant reduction in depressive symptoms and bodily complaints was found in the secondary outcome measures for both treatments in comparison with the WL, but anxiety symptoms were only significantly reduced by ET. In a direct comparison, no significant differences were found between CT and ET in the primary or the secondary outcome measures. Regarding safety behaviors, we found a significantly larger improvement with ET than with CT in the completer analyses. Conclusions: The results suggest high efficacy of CT as well as ET in the treatment of hypochondriasis. Cognitive interventions were not a necessary condition for the change of dysfunctional cognitions. These findings are relevant to the conceptualization and psychotherapeutic treatment of hypochondriasis and health anxiety.
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Karolinska Inst, Stockholm Ctr Psychiat Res & Educ, Dept Clin Neurosci, Stockholm, SwedenKarolinska Inst, Stockholm Ctr Psychiat Res & Educ, Dept Clin Neurosci, Stockholm, Sweden
Nilsson, Anders
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Magnusson, Kristoffer
Carlbring, Per
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Stockholm Univ, Dept Psychol, Stockholm, SwedenKarolinska Inst, Stockholm Ctr Psychiat Res & Educ, Dept Clin Neurosci, Stockholm, Sweden
Carlbring, Per
Andersson, Gerhard
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Karolinska Inst, Stockholm Ctr Psychiat Res & Educ, Dept Clin Neurosci, Stockholm, Sweden
Linkoping Univ, Dept Behav Sci & Learning, Linkoping, SwedenKarolinska Inst, Stockholm Ctr Psychiat Res & Educ, Dept Clin Neurosci, Stockholm, Sweden
Andersson, Gerhard
Hellner, Clara
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Karolinska Inst, Stockholm Ctr Psychiat Res & Educ, Dept Clin Neurosci, Stockholm, SwedenKarolinska Inst, Stockholm Ctr Psychiat Res & Educ, Dept Clin Neurosci, Stockholm, Sweden
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Univ New England, Biddeford, ME 04005 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Herbert, James D.
Forman, Evan M.
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Forman, Evan M.
Kaye, Joanna L.
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Kaye, Joanna L.
Gershkovich, Marina
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Columbia Univ, New York, NY 10027 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Gershkovich, Marina
Goetter, Elizabeth
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Massachusetts Gen Hosp, Boston, MA 02114 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Goetter, Elizabeth
Yuen, Erica K.
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Univ Tampa, Tampa, FL 33606 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Yuen, Erica K.
Glassman, Lisa
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
VA San Diego Healthcare Syst, San Diego, CA USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Glassman, Lisa
Goldstein, Stephanie
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Goldstein, Stephanie
Hitchcock, Peter
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Hitchcock, Peter
Tronieri, Jena Shaw
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Univ Penn, Philadelphia, PA 19104 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Tronieri, Jena Shaw
Berkowitz, Staci
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Univ Penn, Philadelphia, PA 19104 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Berkowitz, Staci
Marando-Blanck, Stephanie
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Drexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA
Univ Massachusetts, Boston, MA 02125 USADrexel Univ, Dept Psychol, 3141 Chestnut St, Philadelphia, PA 10103 USA