Drug repurposing for stroke intervention

被引：18

作者：

Ghosh, Debarati ^{[1
]}

Sehgal, Karan ^{[1
]}

Sodnar, Babasaheb ^{[1
]}

Bhosale, Nikhil ^{[1
]}

Sarmah, Deepaneeta ^{[1
]}

Datta, Aishika ^{[1
]}

Chaudhary, Antra ^{[1
]}

Kalia, Kiran ^{[1
]}

Wang, Xin ^{[2
]}

Bhattacharya, Pallab ^{[1
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmacol & Toxicol, Gandhinagar, Ahmadabad, Gujarat, India

[2] Brigham & Womens Hosp, Harvard Med Sch, Dept Neurosurg, Boston, MA 02115 USA

来源：

DRUG DISCOVERY TODAY | 2022年 / 27卷 / 07期

关键词：

Ischemic stroke; Drug repurposing; Conventional therapy; Recombinant-tissue plasminogen activator; Mechanical thrombectomy; Drug development; INHIBITORS; PREVENTION; COLCHICINE; MECHANISM; STATINS; DESIGN; TARGET;

D O I：

10.1016/j.drudis.2022.03.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite the availability of advanced interventions, stroke remains one of the most significant causes of mortality and morbidity worldwide. US Food and Drug Administration (FDA)-approved treatment options for stroke include tissue plasminogen activators (tPAs) and mechanical thrombectomy (MT). However, these are limited by a narrow therapeutic time window. Additionally, poststroke rehabilitation therapies can provide functional recovery but take a long time to show benefits. Drug repurposing could be a novel approach to broaden treatment options in this scenario. In this review, we summarize marketed drugs that could be repurposed based on their safety and efficacy data. We also briefly discuss their mechanisms of action and provide a list of repurposed drugs under trials for ischemic stroke therapy.

引用

页码：1974 / 1982

页数：9

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