Succinate Dehydrogenase, Succinate, and Superoxides: A Genetic, Epigenetic, Metabolic, Environmental Explosive Crossroad

被引：16
|
作者：
Benit, Paule [1 ]
Goncalves, Judith [2 ]
El Khoury, Riyad [3 ]
Rak, Malgorzata [1 ]
Favier, Judith [2 ]
Gimenez-Roqueplo, Anne-Paule [4 ]
Rustin, Pierre [1 ]
机构：
[1] Univ Paris Cite, INSERM, NeuroDiderot, F-75019 Paris, France
[2] Univ Paris Cite, Paris Ctr Rech Cardiovasc PARCC, INSERM, F-75015 Paris, France
[3] Amer Univ Beirut, Dept Pathol & Lab Med, Neuromuscular Diagnost Lab, Beirut 11072020, Lebanon
[4] Hop Europeen Georges Pompidou, Assistance Publ Hop Paris AP HP, Dept Med Genom Tumeurs & Canc, F-75015 Paris, France
来源：
BIOMEDICINES | 2022年 / 10卷 / 08期
关键词：
mitochondria; respiratory chain; Krebs cycle; succinate; cancer; encephalopathy; SDH; SDHI; mitotoxic; oxytoxic; pesticides; MITOCHONDRIAL COMPLEX-II; TRICARBOXYLIC-ACID CYCLE; RESPIRATORY-CHAIN; ELECTRON-TRANSPORT; QUINONE OXIDOREDUCTASES; OXIDATIVE STRESS; MUTATIONS; INHIBITION; FLAVOPROTEIN; DEFICIENCY;
D O I：
10.3390/biomedicines10081788
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Research focused on succinate dehydrogenase (SDH) and its substrate, succinate, culminated in the 1950s accompanying the rapid development of research dedicated to bioenergetics and intermediary metabolism. This allowed researchers to uncover the implication of SDH in both the mitochondrial respiratory chain and the Krebs cycle. Nowadays, this theme is experiencing a real revival following the discovery of the role of SDH and succinate in a subset of tumors and cancers in humans. The aim of this review is to enlighten the many questions yet unanswered, ranging from fundamental to clinically oriented aspects, up to the danger of the current use of SDH as a target for a subclass of pesticides.
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页数：21
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