Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation

被引：51
|
作者：
Thimmegowda, N. R. [2 ]
Swamy, S. Nanjunda [2 ,3 ]
Kumar, C. S. Ananda [2 ]
Kumar, Y. C. Sunil [2 ]
Chandrappa, S. [2 ]
Yip, George W. [1 ]
Rangappa, K. S. [2 ]
机构：
[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Anat, Singapore 117597, Singapore
[2] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India
[3] Sri Jayachamarajendra Coll Engn, Dept Biotechnol, Mysore 570006, Karnataka, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/j.bmcl.2007.08.078
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel series of trisubstituted benzimidazole and its precursors (3-7) were synthesised and characterized by using H-1 NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-eyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (3) was the potent inhibitor. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：432 / 435
页数：4
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