Preparation of potassium alkoxymethyltrifluoroborates and their cross-coupling with aryl chlorides

被引：68
|
作者：
Molander, Gary A. [1 ]
Canturk, Belgin [1 ]
机构：
[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 11期
关键词：
D O I：
10.1021/ol800532p
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A wide variety of alkoxymethyltrifluoroborate substrates were prepared via S(N)2 displacement of potassium bromomethyltrifluoroborate with various alkoxides in excellent yields. These alkoxymethyltrifluoroborates were effectively cross-coupled with several aryl chlorides. This method provides a unique dissonant disconnect that allows greater flexibility in the design of new and improved synthetic pathways.
引用
收藏
页码：2135 / 2138
页数：4
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