A fully synthetic vaccine consisting of a tumor-associated glycopeptide antigen and a T-Cell epitope for the induction of a highly specific humoral immune response

被引：109

作者：

Dziadek, S

Hobel, A

Schmitt, E

Kunz, H

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Inst Immunol, D-55101 Mainz, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 46期

关键词：

antigens; antitumor agents; glycopeptides; synthetic vaccines; T-cell epitope;

D O I：

10.1002/anie.200501594

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) On target: With the fully synthetic vaccine 1 consisting of a tumor-associated sialyl-Tn glycopeptide antigen from the epithelial mucin MUC1 and a T-cell epitope from ovalbumin, a strong, highly specific immune response (IgG) directed against the glycopeptide antigen was induced in a mouse thereby realizing the most important requirement for the development of synthetic vaccines for the initiation of the body's own immune defense against tumors. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7630 / 7635

页数：6

共 50 条

[31] Tumor-associated B cells and humoral immune response in head and neck squamous cell carcinoma (HNSCC)
Thelen, M.
Lechner, A.
Schloesser, H.
Rothschild, S.
Wennhold, K.
Beutner, D.
von Bergwelt-Baildon, M.
ONCOLOGY RESEARCH AND TREATMENT, 2017, 40 : 251 - 251
[32] T-CELL RECOGNITION OF A TUMOR-ASSOCIATED GLYCOPROTEIN AND ITS SYNTHETIC CARBOHYDRATE EPITOPES - STIMULATION OF ANTICANCER T-CELL IMMUNITY INVIVO
HENNINGSSON, CM
SELVARAJ, S
MACLEAN, GD
SURESH, MR
NOUJAIM, AA
LONGENECKER, BM
CANCER IMMUNOLOGY IMMUNOTHERAPY, 1987, 25 (03) : 231 - 241
[33] A SPECIFIC T-CELL RECEPTOR GENOTYPE PREFERENCE IN THE IMMUNE-RESPONSE TO A SYNTHETIC PLASMODIUM-FALCIPARUM MALARIA VACCINE
MURILLO, LA
TENJO, FA
CLAVIJO, OP
OROZCO, MA
SAMPAIO, S
KALIL, J
PATARROYO, ME
PARASITE IMMUNOLOGY, 1992, 14 (01) : 87 - 94
[34] Induction of antiidiotypic immune response with autologous T-cell vaccine in patients with multiple sclerosis
I. P. Ivanova
V. I. Seledtsov
G. V. Seledtsova
S. V. Mamaev
A. V. Potyemkin
D. V. Seledtsov
V. A. Kozlov
Bulletin of Experimental Biology and Medicine, 2008, 146 : 133 - 138
[35] Induction of Antiidiotypic Immune Response with Autologous T-cell vaccine in Patients with Multiple Sclerosis
Ivanova, I. P.
Seledtsov, V. I.
Seledtsova, G. V.
Mamaev, S. V.
Potyemkin, A. V.
Seledtsov, D. V.
Kozlov, V. A.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 146 (01) : 133 - 138
[36] The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus pneumoniae is dependent on the type of antigen
Wu, ZQ
Shen, Y
Khan, AQ
Chu, CL
Riese, R
Chapman, HA
Kanagawa, O
Snapper, CM
JOURNAL OF IMMUNOLOGY, 2002, 168 (11): : 5551 - 5557
[37] A CD8 T-Cell Epitope Variant Enhances Immune Targeting to a Recombinant Picornavirus Vaccine Antigen
Bell, Michael P.
Renner, Danielle N.
Johnson, Aaron J.
Pavelko, Kevin D.
VIRAL IMMUNOLOGY, 2014, 27 (07) : 361 - 366
[38] Colinear synthesis of an antigen-specific B-cell epitope with a 'promiscuous' tetanus toxin T-cell epitope: a synthetic peptide immunocontraceptive
OHern, PA
Liang, ZG
Bambra, CS
Goldberg, E
VACCINE, 1997, 15 (16) : 1761 - 1766
[39] Processing of tumor-associated antigen by the proteasomes of dendritic cells controls in vivo T-cell responses
Chapatte, Laurence
Ayyoub, Maha
Morel, Sandra
Peitrequin, Anne-Lise
Levy, Nicole
Servis, Catherine
Van den Eynde, Benoit J.
Valmori, Danila
Levy, Frederic
CANCER RESEARCH, 2006, 66 (10) : 5461 - 5468
[40] Identification of an immunogenic CD8+ T-cell epitope derived from γ-globin, a putative tumor-associated antigen for juvenile myelomonocytic leukemia
Hirano, Naoto
Butler, Marcus O.
Xia, Zhinan
Berezovskaya, Alla
Murray, Andrew P.
Ansen, Sascha
Kojima, Seiji
Nadler, Lee M.
BLOOD, 2006, 108 (08) : 2662 - 2668

← 1 2 3 4 5 →