Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions

被引：4
|
作者：
Kastovsky, Jakub [1 ,2 ]
Linhartova, Petra Borilova [1 ,2 ]
Musilova, Kristina [1 ]
Zackova, Lenka [3 ]
Kukletova, Martina [1 ]
Kukla, Lubomir [4 ]
Holla, Lydie Izakovicova [1 ,2 ]
机构：
[1] Masaryk Univ, Clin Stomatol, St Annes Fac Hosp, Brno, Czech Republic
[2] Masaryk Univ, Dept Pathophysiol, Brno, Czech Republic
[3] Masaryk Univ, Stomatol Res Ctr, Fac Med, Brno, Czech Republic
[4] Masaryk Univ, Res Ctr Tox Cpds Environm RECETOX, Chem Sect, Fac Sci, Brno, Czech Republic
来源：
CARIES RESEARCH | 2017年 / 51卷 / 06期
关键词：
BMP2; Case-control study; Dental caries; DLX3; Gene polymorphism; SUSCEPTIBILITY; EXPERIENCE; IDENTIFICATION; TRANSCRIPTION; MUTATION; AMELX;
D O I：
10.1159/000479828
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The aim of this study was to analyze the association between BMP2 (rs1884302) and DLX3 (rs2278163) gene polymorphisms and dental caries in primary and permanent dentitions. A total of 914 subjects were genotyped by the TaqMan methods: 176 caries-free children (with Decayed/Missing/Filled Teeth, DMFT = 0), 542 patients with dental caries in permanent dentition (DMFT >= 1), 83 caries-free children with primary teeth (with decayed/missing/filled teeth, dmft = 0), and 113 children with early childhood caries (ECC, dmft >= 1). There were no significant differences in allele/genotype frequencies between patients with caries in permanent dentition/ECC and caries-free children or between patients with very low (DMFT = 0-2), low (DMFT = 3-5), moderate (DMFT = 6-8), or high (DMFT >= 9) caries experience. Variability in BMP2 and DLX3 was not associated with caries in the Czech population. (c) 2017 S. Karger AG, Basel
引用
收藏
页码：590 / 595
页数：6
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